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Furthermore, in line with findings from 92 that reported reduced proteasome activity in SH-SY5Y dopaminergic cells following USP14 knockout, and 52 , that reported impaired proteasome function in OLN-t40 oligodendroglial cells upon global DUB inhibition by PR619, we observed diminished CT-L proteasome activity following chronic (24 h) DUB inhibition in iNeurons

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