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For example, endogenous fasting levels of ghrelin predict activation of brain regions involved in reward processing in response to pictures of highly caloric and palatable food, including the caudate, amygdala, anterior cingulate, hippocampus, insula, and orbitofrontal cortex (OFC) [22,23]

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265 Additionally, activation of the Wnt/-catenin signaling pathway has been shown to inhibit IL-1-induced apoptosis of intestinal epithelial cells, increase the expression of ZO-1 and Occludin, improve the structure and function of the intestinal barrier, and reduce inflammatory cell infiltration