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As used herein, the term "a rapamycin" is understood to include sirolimus (rapamycin), temsirolimus, everolimus, and ridaforolimus, and related compounds, and compounds of the formula and pharmaceutically acceptable salts thereof, wherein Y A is OR c or OCH 2 CH 2 OR c

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In the outer mitochondrial membrane, medium- and long-chain fatty acids esterified to CoA are transesterified to carnitine in a reaction catalyzed by carnitine palmitoyltransferase I (CPTI)

Alternatively, split the 500mg dose into two 250mg injections given on the same day in different sites