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50 Annular stabbing with needles in animal model consistently triggers disc degeneration, characterized by loss of disc height, hydration and proteoglycans and by the expression of inflammatory, catabolic and fibrotic proteins

other components cleared more rapidly The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all four components and their potential interactions

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Approximately 50 to 250 grams of pollen can be collected by forager bees of one colony per day, while 14 to 40 kilograms of pollen collected by forager bees each year (4, 14)