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Immunometabolism in the pathogenesis of vitiligo is one of the most attractive research areas, which raised by the melanocytes from vitiligo patients are more susceptible to oxidative stress and finally lead to activation of the innate immune response and subsequently to adaptive immune response through activation of autoreactive cytotoxic CD8 + T cells

1 As the disease progresses, treatment intensification becomes necessary, with many individuals ultimately requiring injectable therapies to achieve optimal glycemic control

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