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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

Please do not underestimate sleep [00:50:00] optimization when it comes to metabolic health

10.1016/j.jtcms.2020.10.005 520 ZhouS.-Y.GuoZ.-N.YangY.QuY.JinH

And the Aon multi-year study found something even more striking: among patients who maintained consistent use, the rate of medical cost growth was cut roughly in half within two years