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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, et al

Ann N Y Acad Sci 2008;1127:92-100 DHooghe TM, Debrock S, Hill JA, Meuleman C

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