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See how RYBELSUS measured up vs multiple treatments for type 2 diabetes in the PIONEER phase 3 clinical trial program Bring A1C down with the proven efficacy of RYBELSUS 26-WEEK RESULTS Superior A1C reduction vs Jardiance (empagliflozin) 1 Superior A1C control vs Jardiance 1,2* PIONEER 2 study design 1,2 In an open-label trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 822 adult patients with type 2 diabetes on metformin were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily

After multiple doses, mean IGF-1 levels remained above baseline for up to 28 days, with no serious adverse reactions reported establishing the GHRH-analogue backbone as capable of sustained, clinically meaningful GH and IGF-1 axis elevation