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This work was partially supported by the Ministry of Science and Technology (China) grants (2018YFA0507002 to H.E.X.)

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The STEP program evaluated semaglutide for weight management across distinct populations non-diabetic obesity, type 2 diabetes with obesity, and regimens pairing the drug with intensive behavioral therapy and showed a consistent pattern of clinically meaningful weight loss, with patients who have diabetes generally losing somewhat less than those without