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A review of the relevant literature and the National Institute of Health clinical trial registry did not yield evidence that such a study has been published or is currently underway
doi: 10.1007/s10681-006-9344-8 132 MenkirA.KlingJ
The activation of microglia directly results in the secretion of proinflammatory cytokines in the CNS, which may attract peripheral monocytes to further promote neuroinflammation (Miller and Raison, 2016
In the endothelium MAPK activation by insulin results in increased expression of endothelin-1 (ET-1), plasminogen activator inhibitor type-1 (PAI-1), and the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin
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