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Simply id of DEMs was retrieved from ChemSpider ( Metabolome and transcriptome relationships were visualized using Cytoscape (version 3.5.1)

Although technical hurdles once limited blood-based detection, innovations like single-molecule array (Simoa) and mass spectrometry have enabled plasma quantification of key biomarkers such as the A 142 /A 140 ratio, p-tau18, p-tau217, and NfL, which presumptively reflect central pathology with increasing accuracy

, What GLP-1 and GLP-1/GIP Medications Do for Inflammation 1) They Reduce Chronic Metabolic Inflammation Obesity and insulin resistance are associated with persistent, low-grade metabolic inflammation driven by visceral adiposity, oxidative stress, and hyperglycemia

(Clemmitt, 2024)