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After calorie restriction, CTX levels continued to rise in the combination group owing to further weight loss, but these levels decreased during the final phase of the intervention from week 26 to week 52 across all four groups

Mech Ageing Dev 126(3):389398 Cascalheira JF, Gonalves M, Barroso M, Castro R, Palmeira M, Serpa A, Dias-Cabral AC, Domingues FC, Almeida S (2015) Association of the transcobalamin II gene 776CG polymorphism with Alzheimers type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298AC polymorphism genotype

Their weight loss was accompanied by significant reductions in systolic and diastolic blood pressure, triglyceride levels, and glycosylated hemoglobin

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