can i take semaglutide and metformin Together: Safe Drug Interaction metformin or semaglutide vs Efficacy

ABSTRACT Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin

10.1016/j.jep.2012.09.048 161 WangX.MaJ.ZhangS.LiZ.HongZ.JiangL.et al (2021)

Policy GLP-1 receptor agonists are believed to have anti-inflammatory and neuroprotective effects in addition to the digestion-slowing and glucose-lowering effects shown to be helpful for treating obesity, Type 2 diabetes and cardiovascular disease

However, the *perception* of blood sugar dropping can trigger vasovagal responses: heart rate increases, blood vessels constrict, and dizziness follows even if measured glucose remains safe