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GLP-1RA can reduce ectopic fat through appetite suppression and weight loss, improving insulin sensitivity, enhancing fatty acid oxidation, through anti-inflammatory and directly through tissue-specific action via GLP-1 receptors in liver, heart, pancreas and brain [72,73,74,75]

In general, when hyperglycaemia is corrected in individuals with type 2 diabetes using a variety of interventions, including sulfonylureas and insulin, GIP sensitivity can be restored [32, 33]

Supplementary Tables S1 , S2 include a chi-square test for grouped patients, considering the data as a whole

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