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76 Studies have shown that within various cell types, including vascular smooth muscle cells, endothelial cells, adipocytes, hepatocytes, pancreatic islet cells, and renal tubular cells, uric acid can activate NADPH oxidase, a crucial enzyme involved in the generation of reactive oxygen species

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Maintenance phase: Once your levels are healthy and symptoms improve, we move to a maintenance schedule, which might be a monthly shot or a return to high-dose oral supplements if your absorption allows

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