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These effects are typically mild initially, as starting doses (0.25 mg weekly for both Ozempic and Wegovy) are intentionally low to allow your body to adjust

Over-the-counter remedies: If nausea is moderate, over-the-counter options like bismuth subsalicylate can help

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Meet our doctors Last reviewed: 16 Apr 2026 Sources Effectiveness of Low Doses of Semaglutide on Weight Loss and Body Composition Among Women in Their Menopause, Metabolic Syndrome and Related Disorders [accessed 10 April 2026] GLP-1 medicines for weight loss and diabetes: what you need to know, GOV.UK [accessed 10 April 2026] Semaglutide: Indications and dose, National Institute for Health and Care Excellence (NICE) [accessed 10 April 2026] Treatment - Obesity, NHS [accessed 10 April 2026] Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen (PIL), emc [accessed 10 April 2026]