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Figure S18

The method of claim 1 , wherein the PDE-5 inhibitor is administered so as to maintain a steady-state plasma concentration and PT-141 is administered at anytime thereafter

The fasting treatment consisted of 2 days with moderate calorie restriction (700800 Kcal/day), 5 days of intense calorie restriction (200 Kcal/day), followed by 3 days with the stepwise reintroduction of a normal diet

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