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In a meta-analysis of 10 placebo-controlled trials including over 71,000 subjects with or without diabetes at recruitment, treatment with SGLT2 inhibitors reduced the risk of heart failure hospitalization or cardiovascular death by 24% and lowered the risk of poor renal outcomes by 32% (Barbarawi 2021)
So, you're sort of flying blind if you decide to give this a try
Studies show that B12 helps decrease homocysteine levels, which may lower the risk of heart disease
[2] In addition to assisting with vitamin deficiencies, this vitamin may assist in treating metabolic disorders such as subacute necrotizing encephalomyelopathy, branched-chain aminoacidopathy and lactic acidosis associated with pyruvate carboxylase deficiency
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