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Amazing turn of events from Eli Lilly, and I believe highly relevant to our recent investigation which shows that GLP-1R and GIPR work primarily by engaging the AKAP SPHKAP, a prominent factor involved in bipolar disorder and schizophrenia: Fascinating
Consequently, oxidative stress and inflammation interact to promote the development of neurodegenerative diseases
ALS is also caused by mutations in the genes encoding the DNA/RNA-binding proteins: TAR DNA-binding protein 43 (TDP43) and fused in sarcoma/translocated in liposarcoma (FUS), the ubiquitin-like protein Ubiquilin 2 [8], angiogenin, the actin-binding protein profilin [13], valosin-containing protein (VCP) (or transitional endoplasmic reticulum ATPase), and optineurin [4, 9, 10]
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