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KEGG pathway analysis of downregulated (upper panel) and upregulated (lower panel) genes in Bmal1 -KO vs

RT was done with a RevertAid H cDNA Synthesis Kit (Thermo Fisher Scientific, USA) according to manufacturers instructions using both TMV coat protein gene reverse primer ( TMV-CP rev) and an oligo-dT primer

Conversely, loss of ROR disrupts bile acid rhythmicity, impairs FXRFGF15 signaling, reduces fatty acid oxidation, and produces severe hepatic steatosis, particularly under metabolic stress (44)

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