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10.3390/jpm11030168 J Personal Med

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Keywords : Phospholipase C, cancer development, intracellular signaling, oncogene, tumor suppressor Phospholipase C (PLC) family, consisting of 6 subgroups - PLC, , , , , , is a group of proteins able to hydrolyze membrane phosphoinositol 4,5-bisphosphates (PIP2) to inositol-1,4,5-phosphate (IP3) and diacylglycerol (DAG) - both important second messengers - in response to extracellular stimuli including hormones and growth factors through activation of the different receptor tyrosine kinases (RTK) or G-protein-coupled receptors (GPCR) [1]

In a cancer setting, M1 macrophages generally promote inflammation and active antitumor immune responses