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Published online June 27, 2014

As shown in Table 3 and Fig

Although they are not able to catalyze glutathione S -conjugation reactions at significant rates, they are considered to belong to the glutathione S -transferase (GST) superfamily (Dixon and Edwards, Glutathione peroxidase (GPX) Although GSSG could be generated as a product of GSH-dependent DHA reduction, genomics has revealed the complexity of the plant antioxidative system and identified several GSH-dependent enzymes that may play more direct roles in peroxide metabolism

The downstream effects include: Synaptogenesis : Formation of new synaptic connections in hippocampal neurons, driven by c-Met-mediated activation of PI3K/AKT and MAPK/ERK signaling cascades Spinogenesis : Growth of new dendritic spines, the structural substrate for excitatory synaptic transmission Neurotrophic support : In cell-based neurotrophic assays, Dihexa demonstrated potency approximately seven orders of magnitude greater than BDNF The HGF/c-Met pathway is distinct from the BDNF/TrkB and NGF/TrkA pathways targeted by most nootropic peptides