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For tirzepatide in particular, faster absorption from a highly vascular site can intensify early side effects, while slower absorption from thicker fat can reduce the drug's peak effectiveness early in the week

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It can make high blood pressure harder to control, raise the risk of type 2 diabetes, worsen sleep apnea, increase inflammation, and make the heart work harder than it should

This prevents the miniaturisation of follicles, a common cause of thinning, and supports the retention of healthy hair density