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An optimal protocol should incorporate stratified randomization based on OS biomarker profiles (e.g., plasma MDA, urinary 8-OHdG) to identify subgroups most likely to benefit

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Retatrutide carries the side-effect profile of the GLP-1/GIP class nausea, vomiting, diarrhoea, constipation plus the class-level concerns we know from Mounjaro and Wegovy: gallbladder disease, pancreatitis, kidney injury from severe dehydration, and a possible thyroid C-cell tumour signal seen in rodent studies