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Penetration motifs further strengthen the ability of carriers to traverse the vascular wall and the extracellular matrix and complement particle size and surface properties in efforts to improve tissue penetration [59]

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Critically, this therapeutic contextdecompensated cirrhosis with documented malnutrition and reduced Fischer ratiois mechanistically and clinically distinct from early MASLD or metabolic syndrome, where elevated circulating BCAAs reflect impaired catabolic disposal rather than insufficient intake, and supplementation is not recommended (see Section 6.3 for disease-stage-stratified clinical recommendations)

A study by Gameiro et al