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For example, Novo Nordisk launched its Wegovy pill at $149 per month via a direct-to-consumer model. For employers and health plans this volatility and shift in government pricing benchmarks may eventually cascade into future contract negotiations and formulary structures

Thanks to their expanded interface with the target protein, peptide PROTACs demonstrate superior potency, higher selectivity, and reduced toxicity compared to low molecular weight compounds, especially when targeting proteins lacking well-defined binding pockets (Kargbo, 2019)

Highlighting its importance, dysregulation of ERAD often results in devastating diseases