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Treatment for B12 deficiency without neurological involvement: For patients with haematological manifestations only (macrocytic anaemia) or asymptomatic deficiency, the regimen is hydroxocobalamin 1mg intramuscularly three times weekly for two weeks (total of six injections), followed by maintenance of 1mg every three months for life
Current lab values, medication list, kidney function, and hydration status all factor in
In some cases, especially at the beginning of treatment for a severe deficiency, injections might be given more frequently (e.g., daily or every other day) for a short period before transitioning to a maintenance schedule
[3] Heffernan M, et al
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