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Aumento de la Gnesis y Transporte de Melanina : Las manchas marrones pueden producirse debido a un aumento en la produccin de melanina y su transporte a los queratinocitos, las clulas principales de la epidermis

The synergistic cytotoxic effects of NAR and ferroptosis inducers were reversed when the cells were pretreated with AMPK inhibitors or PGC1 inhibitors, confirming that the inhibition of aerobic glycolysis mediated through the AMPK-PGC1 signaling pathway is crucial for NAR reducing liver cancer resistance to ferroptosis (82)

The scores of the arthritic hind paw determined by the two observers were averaged to obtain the final erosion score 69

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