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Those withdrawal symptoms include irritability, insomnia, depression, weight gain, loss of focus and intense cravings for a cigarette

however, the original source does not have a precise estimate of smoking 2 packs a day

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(1992) studied in guinea-pigs the effects of combined exposure and single exposure to ozone and cigarette smoke on airway responsiveness and tracheal vascular permeability and found that the combined exposure increased airway responsiveness and vascular permeability to a greater extent in terms of magnitude, but not in duration, than a single exposure