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10.1016/j.jaccao.2023.05.013 99 OsataphanN.PhrommintikulA.LeemasawatK.SomwangprasertA.ApaijaiN.SuksaiS.et al (2023)

These symptoms are generally mild and transient, improving as the digestive system adapts to the medication

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However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials