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Summary Takeaway Messages Despite the ability of GLP-1s to produce significant weight reduction and related health benefits, challenges such as GI side effects, risk of nutrient inadequacies, loss of muscle and bone mass, high costs, frequent discontinuation, and weight regain limit the use of these drugs for long-term success in individuals and populations

Hagn, F., Etzkorn, M., Raschle, T

Pre-injection preparation techniques include: Cleaning the injection site with an alcohol swab and allowing it to dry completely (wet alcohol can cause stinging and tissue irritation) Refraining from rubbing or massaging the injection site before or immediately after injection Using standard 4-mm, 32G pen needles, which minimize tissue trauma for most patients Applying firm pressure (without rubbing) with a clean gauze pad or cotton ball for at least 2 minutes after needle withdrawal, especially for patients on blood thinners For patients taking anticoagulants or antiplatelet medications, do not change your medication dosing or timing for injections

e-mail: [email protected] This article was submitted to Frontiers in Molecular and Cellular Oncology, a specialty of Frontiers in Oncology