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For someone on antihypertensive medication, that improvement can push them into symptomatic low blood pressure, especially when standing

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However, if you have been at maximum dose for 12 or more weeks without adequate response, or if side effects prevent further dose increases, switching to tirzepatide is a reasonable next step

September 2023: Nearly six years after launch, the company adds ileus and bowel obstruction warnings after patients suffered excruciating intestinal blockages requiring emergency surgery