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On the other hand, the more tolerant of tobacco plants to pepper mild mottle virus (PMMoV-I) infection characterized decreased activity GR whereas OTC treated tolerant pea characterized GR upregulation ( Figure 2 3 Role of glutathione cycle in regulation of susceptible host-plant virus interaction In contrast to resistance, in susceptible plants, the generation of ROS is not well or properly controlled due to changes induced by plant virus infection in the host cell, particularly in the modulation of glutathione