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Due to this being the first study assessing nicotine pharmacokinetics and subjective effects of the Pulze HTS, no sample size calculations could be performed

As enjoyment of nicotines pleasurable effects are hypothesized mechanisms in the catalyst model, studies of whether e-cigarette nicotine concentration is associated with smoking were also considered as relevant to determining plausibility

Kim HKK, Bae W, Chung JW, Cho YM, Kim YJK, Sohn DW, Park YB: Differences in the immediate effects of smoking on left ventricular diastolic function between healthy volunteers and patients with type 2 diabetes mellitus

The matter is not concluded