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Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility
After 14 days, cells were trypsinized and replated with N2B27 medium on poly-D-lysine/laminin-coated 16-18mm coverslips for terminal differentiation in the presence of BDNF (R&D Systems, 10 ng/ml)
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