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For researchers building a comprehensive IGF axis research workflow, the standard approach is to use IGF-1 LR3 as the primary tool for sustained IGF1R activation studies, native IGF-1 for short-pulse studies where IGFBP biology is itself the research question, and DES IGF-1 for the narrow set of experiments requiring receptor activation with rapid washout

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Any consideration of GLP-1 therapy should involve comprehensive evaluation by an endocrinologist or appropriate specialist, with clear discussion of the investigational nature of this approach, potential risks, costs, and the importance of ongoing monitoring

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