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Important note: The Dexcom Stelo is not recommended for people who experience problematic hypoglycemia (frequent dangerous lows)

The efficacy of a second-generation derivative, omaveloxolone (RTA408), has recently been assessed in a preclinical model for diabetic chronic non-healing wounds [277] and, interestingly, omaveloxolone is now being tested in phase-II clinical trial for the Friedreichs ataxia (FRDA), a neurodegenerative condition in which NRF2 activation is suppressed [278, 279]

Courses are repeated 2 to 4 times per year, typically spaced 3 to 6 months apart

Absorption through the oral mucosa bypasses the injection process entirely, though bioavailability and onset timing differ from subcutaneous administration