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In the phase 2 trial of cagrilintide 2.4 mg co-administered with semaglutide 2.4 mg (CagriSema) in people with type 2 diabetes, the combination improved glycemic control and body weight relative to semaglutide alone, consistent with amylin adding a postprandial glucose-lowering contribution on top of GLP-1 action

Patients should never discontinue semaglutide or alter dosing without medical guidance, as this may compromise glycemic control or weight management outcomes

This guidance followed market confusion caused by illegal counterfeit products and unlicensed online sellers

[1] [2] When food remains in the stomach and upper intestine for longer than usual, it may undergo additional fermentation by gut bacteria