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Among these hypotheses about the mechanisms of sustained antidepressant effect, several studies have highlighted that the focus of the mechanism of sustained antidepressant pharmacodynamics should be centered on the downstream, long-term events of change induced by sustained antidepressant action

Every 15 seconds or when rhythm disturbances occurred, extended recordings were made at 50 mm/s or 100 mm/s

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Free Radical Biol Med (2012) 52(2):43643