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Reducing the levels of this signaling molecule with a drug reproduces some of these positive effects (Thevaranjan et al., 2017)

[55] It suppresses appetite through a dual mechanism: it directly stimulates anorexigenic (satiety-inducing) neurons that express proopiomelanocortin (POMC) and cocaine-and amphetamine-regulated transcript (CART), while simultaneously inhibiting orexigenic (appetite-inducing) neurons that express AgRP and NPY

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