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One potential explanation encompasses the already mentioned continuous exposure to antigen stimulation as well as oxidative stress entailing the production of reactive oxygen species (ROS), which is of great relevance for immune cells with a large amount of polyunsaturated fatty acids (PUFAs) in their plasma membrane, since this makes them vulnerable to lipid peroxidation, causing a loss in plasma membrane integrity which ultimately results in a compromised immune response [13, 17,18,19,20,21]
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