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Lean C57BL/6J mice and genetically obese (ob/ob) mice, all 12 weeks old, were divided into three treatment groups including: saline control, AOD9604 at a dose of 250 g/kg/day, and hGH at a dose of 1 mg/kg/day, with each group consisting of six mice

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They have realistic expectations about the side effect profile and are willing to tolerate gastrointestinal discomfort in the early weeks

One article reports three patients who developed hepatotoxicity when they received continuous 100 hour infusions separated by 16 days for the treatment of complex regional pain syndrome (CRPS)