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Garber, MD, PhD, Professor, Departments of Medicine, Biochemistry & Molecular Biology, and Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas These agents have the potential to change the diabetes treatment paradigm by replacing traditional secretagogues because of superior control, freedom from hypoglycemia, and association with weight loss

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Despite a long history of clinical use, warfarin treatment remains very challenging due to its narrow therapeutic index and large interindividual variability in patient response