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Globally, obesity rates have nearly tripled since 1975, leading to a surge in related conditions like heart disease and stroke

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Testosterone exerts a stimulatory effect on growth hormone secretion at the pituitary level, which is called a push effect. On the other hand, estrogen increases growth hormone secretion only through its inhibitory effect on insulin-like growth factor-I production in the liver with resultant feedback stimulation of growth hormone release from the pituitary: a pull effect (5)