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GNE inhibition results in hyposialylation of IGF-1R Since the key function of GNE is epimerization and phosphorylation of precursors in the sialic acid biosynthetic pathway, absence of functional GNE would cause hyposialylation and affect sialylation of cell surface receptors 15,30

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Pro Glutathion proto dodv cystein ve stabilizovan form jako N-acetylcystein (chemicky sprvn N-acetyl-L-cystein, znm tak jako NAC)

doi: 10.1016/j.cell.2021.06.019 67