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A phase II, Randomized, Double-Blind, placebo-controlled study of Simtuzumab in Combination with FOLFIRI for the second-line treatment of metastatic KRAS Mutant Colorectal Adenocarcinoma

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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)