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GLP-1 medications are no longer used only for diabetes
Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
Nasrallah & Alzeer, 2022) and post-mortem studies(Chauhan et al., 2012
The BuOH fraction was found to be constituted by a complex mixture of components, as shown in its HPLC chromatogram (Figure 1A)
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