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Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site

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This biological hunger can hit all at once, leading to a restart of the binge cycle even when on medication , or can come back with a vengeance when finishing weight loss medication , if binge eating patterns have not been addressed separately

Its structure is what lets it bind GLP-1 receptors and trigger the downstream effects on insulin secretion, appetite and gastric emptying the article describes