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When co-formulated with 300 mg SNAC, 1% of semaglutide is usually absorbed in the stomach.[13] DOSE FINDING STUDY Based on a dose-finding study (Phase 2 trial) in which different doses of oral semaglutide (2.5, 5, 10, 20 and 40 mg) were studied and three doses of oral semaglutide 3, 7 and 14 mg were selected for phase 3 trials to have optimal benefitrisk profiles

The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability