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Proinflammatory cytokines produced by microglia and astrocytes upon activation cause upregulation of MMP-9 expression in endothelial cells, which results in the degradation of tight junction proteins and causes the breakdown of the BBB (223)
Since then, researchers have explored the molecular mechanism of ferroptosis and elaborated upon in detail below (Fig
As cathepsin B has been previously reported to play a significant role in promoting cell death during liver injury (Guicciardi et al., 2000), it may be anticipated that APAP-mediated release of lysosomal cathepsin B may contribute to APAP-induced liver injury
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